Mohammad Ali Talpur was born in 1976 in Tando Jam, Sindh.
He spent his childhood in his home town Tando Jam then he moved to Lahore. He got his BFA degree in 1998 from the National College of Arts, Lahore. He is teaching at National College of Arts and works at his studio in Lahore.
His work passed through various phases to get its unique identity. He is known for his linear drawings, and these drawings reflect the magical quality that a viewer can not resist to pass through the inner essence of visual pleasure. He creates drawings like poetry by arranging the cluster of lines on paper and deliberately states “art without content” which interpret the existence of life.